What is isotonitazene?
Isotonitazene is known to be a benzimidazole derived opioid analgesic drug associated with etonitazene, which is sold mostly as a designer drug in the market. It consists of only about half the potency of etonitazene in animal studies, but it still tends to demonstrate similar strength to that of fentanyl and its analogues. Consequently, isotonitazene is expected to pose a substantial risk of creating hazardous and dangerous respiratory problems, as well as various other typical opioid side effects including nausea, vomiting, sedation, and so on.
History and review of Isotonitazene
Isotonitazene, purchased from an online vendor, was entirely characterized in November 2019 in a paper in which the authors performed a complete analytical structure elucidation, besides determining the potency of the μ opioid receptor with the help of a biological functional assay in vitro. Isotonitazene was not compared directly to morphine in this particular assay, but it was instead found o be around 2.5 times more potent than hydromorphone and even a bit more potent than fentanyl.
A designer drug can be defined as a functional or structural analog of a controlled substance which is mainly designed to imitate the pharmacological effects of the original drug, and that too while avoiding classification as illegal. Designer drugs tend to include psychoactive substances designated by the EU as new psychoactive substances or analogs of performance-enhancing drugs.
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